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This results in decreased autophagy and increased apoptosis, contributing to Schwann cell dysfunction

At 12 weeks, participants saw a 9.43-kilogram (20.7 pound) reduction in body weight, 3.35 reduction in BMI, and an 8.29-kilogram (18.2 pound) reduction in fat body mass

According to the recommended dosing schedule, tirzepatide is initiated at 2.5 mg weekly and increased in 2.5 mg increments every four weeks until the maximum tolerated dose is reached, with 15 mg being the highest approved dose [17]