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Firestein & Kelley's Textbook of Rheumatology

Gs/cAMP Transcription and Somatostatin Suppression GHSR-1a also couples to Gs protein adenylyl cyclase cAMP PKA

After hydrolysis, IMP and GMP are converted, under the action of other enzymes, to hypoxanthine and xanthine, which serve as substrates for XDH, thereby increasing the consumption of hypoxanthine and the production of uric acid in the liver (107)

They also have two effects on the biliary system that, together, substantially increase the risk of gallstone disease: Rapid weight loss alters bile composition