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Secondary efficacy endpoints included proportion of participants achieving body weight loss of 5% or more and 10% or more from baseline to week 24, change from baseline to week 24 in body weight, waist circumference and BMI, change from baseline to week 24 in glucose metabolism parameters (HbA1c, fasting plasma glucose and fasting insulin), changes from baseline to week 24 in cardiovascular risk factors (blood pressure, lipids [total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides]), changes from baseline to week 12 and week 24 in serum uric acid and ALT, changes in IWQOL-Lite scores, as well as changes from baseline to week 36 in body weight, waist circumference, BMI, glucose and cardio-metabolic risk factors