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The Hp1/2 proteins form different oligomers, such that a dimeric Hp11 molecule can bind two haemoglobin dimers, while the polymeric Hp21 and Hp 22 molecules have the capacity to bind greater numbers of haemoglobin dimers (Morton et al., 2006)

Swelling in brain cells can lead to severe neurological symptoms, including seizures or coma

Recent studies have identified the potential use of SHIN1 for the purpose of treating mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) [157]

Treatment should be initiated and supervised within specialist weight management services and is typically recommended for a maximum of 2 years