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Given that folate is not biologically active, it necessitates transformation into tetrahydrofolate that is then converted into methylenetetrahydrofolate (MTHF) by the enzyme methylenetetrahydrofolate reductase (MTHFR) [19]

[DOI] [PubMed] [Google Scholar] 90.Masaki T, Yoshimatsu H, Chiba S, Watanabe T, Sakata T

Nevertheless, there is a lack of the relevant cell lines to model the whole sophisticated cell interaction for both BBB and BCB, which is especially problematic for the latter since it is combined with a more model-challenging barrier geometry (Strazielle and Ghersi-Egea, 2011)

Therefore, inhibition of TXNIP should increase Trx1 activity