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Nutrients 12:3759

The Origins of the Herx Reaction The classic Jarisch-Herxheimer Reaction (JHR) is a set of symptoms starting within a few hours of antibiotic treatment for infections caused by Spirochetes bacteria, such as Treponema pallidum (the cause of syphilis) 1 2

median follow-up 2.1 years), which proved instrumental in the approval process

Conclusion Although topical glutathione shows promise for dermatological applications, further larger randomized controlled trials with long-term follow-up are necessary to evaluate its utility more comprehensively in improving hyperpigmentation, erythema, and reducing free-radical damage