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doi: 10.1038/s41467-018-05470-4 212 RobertsonM

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Treatment with propargylglycine (PAG) [16], a pharmacological inhibitor of the key enzyme in the transsulfuration pathway that catalyzes the hydrolysis of cystathionine into cysteine, cystathionine -lyase (CSE), was sufficient to sensitize two MYCN -amplified NB cell lines to system Xc-inhibition ( Fig