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Many of these risk factors are either directly or indirectly related to stresses that act on the BBB, and these stresses can result in different mechanisms of BBB dysfunction

Using transcriptomic, chemical and biochemical approaches, we discover that rather than directly targeting bacteria, KL1 consistently reduces host ROS/RNS

As described above, inhibition of IL-6 trans-signaling has been shown to mitigate inflammation responses (Risby-Jones et al., 2025), and targeting miRNAs has a potential to modulate glial cell functions (Hoye et al., 2018

At 24 weeks of age, all the rats were sacrificed, and examined by biochemical tests and had their adipose tissue weight measured