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Nature Communications , 16 (1), 2876 Wu, X., Yuan, H., Wu, Q., Gao, Y., Duan, T., Yang, K., Huang, T., Wang, S., Yuan, F., Lee, D., Taori, S., Plute, T., Heissel, S., Alwaseem, H., Isay-Del Viscio, M., Molina, H., Agnihotri, S., Hsu, D

As with other incretin-based therapies, the most commonly reported side effects of retatrutide in clinical trials are gastrointestinal in nature

There is no evidence of clinically significant immunosuppression with semaglutide in clinical trials or in the UK Summary of Product Characteristics (SmPC)

Studies have demonstrated that long-term PPI use can change the composition of the gut microbiota and lead to bacterial translocation from the oral cavity to the intestinal lumen (Shi et al., 2019