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[PMC free article: PMC5228196] [PubMed: 28101361] [CrossRef] 186

Previous studies showed that the basal blood glucose level of GLP-1R KO mice was upregulated over that of WT mice [57, 58]

Elevated glutamate levels can cause intracellular calcium overload via N-methyl-D-aspartate ionotropic receptors (NMDAR) and metabotropic glutamate receptors