p95/NBS1(Phospho-Ser343) Rabbit Polyclonal Antibody, 50ul Culture Media Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding multiple isoforms have been observed for MARK4

This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways

which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain

When a proteinase cleaves the bait region

p95/NBS1(Phospho-Ser343) Rabbit Polyclonal Antibody, 50ul Culture Media Alternatively spliced transcript variants encodingMutations in this gene are associated with Nijmegen breakage syndrome an autosomal recessive chromosomal instability syndrome characterized by microcephaly growth retardation immunodeficiency and cancer predisposition. The encoded protein is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint