ORCTL2 Polyclonal Antibody, 50ul Cellular Cultivation & Health Management The encoded protein has a

The encoded protein has a low level of testosterone hydroxylase activity

and its alternative splicing generates 3 transcript variants

ranging from neonatal adrenoleukodystrophy to Zellweger syndrome

The encoded protein has been shown to interact with the cancer developmental regulators SMAD2

ORCTL2 Polyclonal Antibody, 50ul Cellular Cultivation & Health Management The encoded protein has aSLC22A18 is one of several tumor suppressing subtransferable fragments located in the imprinted gene domain of 11p15. , an important tumor suppressor gene region. Alterations in this region have been associated with the Beckwith Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. SLC22A18 is imprinted, with preferential expression from the maternal allele. Mutations in SLC22A18 have been