DLEC1 Polyclonal Antibody, 50ul Pathway and Network Analysis This gene was demonstrated to

This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue

A chromosomal translocation involving this gene and the IgH locus

It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization

Multiple alternatively spliced transcript variants have been described

DLEC1 Polyclonal Antibody, 50ul Pathway and Network Analysis This gene was demonstrated toThe cytogenetic location of DLEC1 (deleted in lung and esophageal cancer 1) is 3p21. , and it is located in a region that is commonly deleted in a variety of malignancies. Down regulation of DLEC1 has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of DLEC1 in tumor cells is a result of aberrant promoter methylation. Several alternatively