HIF-1 Alpha Polyclonal Antibody, 50ul[BT-AP03965] Molecular Sciences Component of the AP-1 transcription

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins

Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini

tissue specificity:Expressed in brain and leukocytes

Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease)

HIF-1 Alpha Polyclonal Antibody, 50ul[BT-AP03965] Molecular Sciences Component of the AP-1 transcriptionHIF1A encodes the alpha subunit of transcription factor hypoxia inducible factor 1 (HIF 1), which is a heterodimer composed of an alpha and a beta subunit. HIF 1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic