Rat Growth/Differentiation Factor 11, GDF11 ELISA Kit, 96T DNA/RNA Isolation & Purification Present mainly in the mitochondrial

Present mainly in the mitochondrial compartment of peripheral tissues

Under conditions of nutrient depletion

stimulating IRF5 homodimerization and translocation into the nucleus (By similarity)

This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm

Rat Growth/Differentiation Factor 11, GDF11 ELISA Kit, 96T DNA/RNA Isolation & Purification Present mainly in the mitochondrialSecreted signal that acts globally to specify positional identity along the anterior posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Signals through activin receptors type 2, ACVR2A and ACVR2B, and activin receptors type 1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.