ING5 Polyclonal Antibody, 50ul Enzyme Activity Assays POLR2E (RNA polymerase II subunit

POLR2E (RNA polymerase II subunit E) encodes the fifth largest subunit of RNA polymerase II

Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome

Mg2+/Mn2+ dependent 1K

Mutations in this gene have been associated with atrial fibrillation familial type 6

ING5 Polyclonal Antibody, 50ul Enzyme Activity Assays POLR2E (RNA polymerase II subunitThis gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants.