ALS2 Polyclonal Antibody, 100ul Nucleic Acid Extraction An important paralog of RNF144B

An important paralog of RNF144B is RNF19A

The protein also has rho-GTPase activity

is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information

Members of this family share a conserved motif termed

ALS2 Polyclonal Antibody, 100ul Nucleic Acid Extraction An important paralog of RNF144BThe protein encoded by this gene contains an ATS1 RCC1 like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics.