FBX10 Rabbit Polyclonal Antibody, 50ul Reservoirs Mutations in this gene have

Mutations in this gene have been associated with maturity-onset diabetes of the young

which carries most of the O-linked glycosylation (Gendler and Spicer

an adapter module in different E3 ubiquitin ligase complexes (By similarity)

two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase

FBX10 Rabbit Polyclonal Antibody, 50ul Reservoirs Mutations in this gene haveMembers of the F box protein family such as FBXO10 are characterized by an approximately 40 amino acid F box motif. SCF complexes formed by SKP1 (MIM 601434) cullin (see CUL1; MIM 603134) and F box proteins act as protein ubiquitin ligases. F box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains (Jin et al. 2004