MICU1 Monoclonal Antibody(Mix), 50ul Pathway and Network Analysis Defects in complex I are

Defects in complex I are a common cause of mitochondrial dysfunction

alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms

Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias

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MICU1 Monoclonal Antibody(Mix), 50ul Pathway and Network Analysis Defects in complex I areThis gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.