MDM2 Polyclonal Antibody, 50ul[BT-AP05301] Drug Development and Evaluation Mutations in this gene have

Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS)

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Cytochrome P450 family 4 subfamily F member 2 localizes to the endoplasmic reticulum

neural tube defects

MDM2 Polyclonal Antibody, 50ul[BT-AP05301] Drug Development and Evaluation Mutations in this gene haveMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many