BRMS-1 Polyclonal Antibody, 50ul[BT-AP00979] Gene Synthesis This isoform (alpha 2) is

This isoform (alpha 2) is expressed in brain

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs)

Mutations in this gene cause karyomegalic interstitial nephritis

This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle

BRMS-1 Polyclonal Antibody, 50ul[BT-AP00979] Gene Synthesis This isoform (alpha 2) isBRMS1 reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. Breast cancer metastasis suppressor 1 encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different