Rb(Phospho Ser811) Polyclonal Antibody, 20ul Micro Centrifuge Tubes HMGB1 encodes a protein that

HMGB1 encodes a protein that belongs to the High Mobility Group-box superfamily

Expressed at lower level in neural tissues and at the highest level in the adrenal gland

Members of this family contain zinc-finger and bZIP DNA-binding domains

called the leukocyte receptor cluster

Rb(Phospho Ser811) Polyclonal Antibody, 20ul Micro Centrifuge Tubes HMGB1 encodes a protein thatThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.