GPR87/95 Polyclonal Antibody, 50ul Mechanical Pipette The other two isoforms| p52Shc

The other two isoforms| p52Shc and p46Shc| link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex

Contains 2 B box-type zinc fingers

The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation| suggesting a cell cycle function

Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes

GPR87/95 Polyclonal Antibody, 50ul Mechanical Pipette The other two isoforms| p52ShcGPR87 encodes a G protein coupled receptor and is located in a cluster of G protein couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID: 18057535) and regulated by p53 (PMID: 19602589).