Topo IIIBeta-1 Polyclonal Antibody, 50ul Micro Centrifuge Tubes Plays an important role in

Plays an important role in tumor suppression through p53/TP53 regulation

Mutations in this gene are associated with congenital stationary night blindness type 2B

Mutations in this gene are associated with Turner type X-linked syndromic mental retardation

The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation| apoptosis| differentiation| the stress response| and regulation of immune genes

Topo IIIBeta-1 Polyclonal Antibody, 50ul Micro Centrifuge Tubes Plays an important role inTOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome