LKB1(Phospho Ser428) Polyclonal Antibody, 50ul Mechanical Pipette MARCH1 downregulates the surface expression

MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment

May function as a transcriptional regulator

With 50 reactions and 1 reaction per microliter

which play a role in cytoskeletal formation by regulating actin polymerization

LKB1(Phospho Ser428) Polyclonal Antibody, 50ul Mechanical Pipette MARCH1 downregulates the surface expressionThis gene, which encodes a member of the serine threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not