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Alternatively spliced transcript variants encoding multiple isoforms have been observed for ITCH

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API5 Polyclonal Antibody, 20ul NGS Oligos Take your research to theAPI5 encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein (apoptosis inhibitor 5) suppresses the transcription factor E2F1 induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants