CCL23 Polyclonal Antibody, 20ul Low-speed Centrifuges This gene is located in

This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17

which may function as a transcription factor

Mutations in this gene cause nephronophthisis (NPHP)| an autosomal recessive kidney disease characterized by tubular basement membrane disruption| interstitial lymphohistiocytic cell infiltration| and development of cysts at the corticomedullary border of the kidneys

MIM 610553) (Komatsu et al

CCL23 Polyclonal Antibody, 20ul Low-speed Centrifuges This gene is located inThis gene is one of several chemokine genes clustered on the q arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower