TBK1 Polyclonal Antibody, 100ul Protein Modification Mutations in this gene are

Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19

They are differentially regulated after early development

The protein encoded by this gene binds DNA and is a component of heterochromatin

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TBK1 Polyclonal Antibody, 100ul Protein Modification Mutations in this gene areThe NF kappa B (NFKB) complex of proteins is inhibited by I kappa B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The TANK binding kinase 1 encoded by TBK1 is similar to IKB kinases and can mediate NFKB activation in response