Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette This gene is widely expressed

This gene is widely expressed in many tissues with the greatest abundance in brain and testis

The protein encoded by this gene is a member of the shugoshin family of proteins

Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly

This gene may be a tumor suppressor gene

Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette This gene is widely expressedCell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical