SirT1(Phospho-Ser27) Rabbit Polyclonal Antibody, 100ul Primary Antibodies while the N-terminal of the

while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA

thereby recruiting histone modifying proteins

Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis

which encode four distinct protein isoforms

SirT1(Phospho-Ser27) Rabbit Polyclonal Antibody, 100ul Primary Antibodies while the N-terminal of theThis gene encodes a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular