ADAM10 Polyclonal Antibody, 50ul PCR Series Defects in EP300 are a

Defects in EP300 are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer

Constitutive activation of this gene caused either by somatic mutations

elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport

The main portion of the receptor is a heterodimer composed of 2 polypeptide chains

ADAM10 Polyclonal Antibody, 50ul PCR Series Defects in EP300 are aMembers of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. ADAM10 encodes and ADAM family member that cleaves many proteins including TNF alpha and E cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing.