Presenilin 1(Phospho Ser357) Polyclonal Antibody, 100ul CellSafe™ E3 ubiquitin-protein ligase that mediates
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Presenilin 1(Phospho Ser357) Polyclonal Antibody, 100ul CellSafe™ E3 ubiquitin-protein ligase that mediatesAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.
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