Ku-70 Polyclonal Antibody, 50ul[BT-AP04893] Serum & Sample Tubes Contains 1 Ig-like C1-type (immunoglobulin-like)

Contains 1 Ig-like C1-type (immunoglobulin-like) domain

The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus

This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation

Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction

Ku-70 Polyclonal Antibody, 50ul[BT-AP04893] Serum & Sample Tubes Contains 1 Ig-like C1-type (immunoglobulin-like)The p70 p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single stranded DNA dependent ATP dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with