HSC70 Monoclonal Antibody(8G7), 50ul Vessels Mutations in the gene encoding

Mutations in the gene encoding ataxin 3 are associated with Machado-Joseph disease

The encoded protein may play a role in metal ion transport

which regulates the phosphorylation and nuclear translocation of TFEB in response to cellular starvation and stress

Overexpression of the encoded protein results in apoptosis

HSC70 Monoclonal Antibody(8G7), 50ul Vessels Mutations in the gene encodingThis gene encodes a member of the heat shock protein 70 family, which contains both heat inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin coated vesicles during transport of membrane components