DMA Polyclonal Antibody, 20ul Immune Repertoire Sequencing Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding distinct isoforms have been observed

Although this locus appears to encode a protein similar to trypsinogen| the locus is thought to be a transcribed pseudogene

Several transcript variants encoding multiple isoforms have been described

Reciprocal translocations between chromosomes 17 and 22| where this gene and the gene for platelet-derived growth factor beta are located| are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans| resulting from unregulated expression of the growth factor

DMA Polyclonal Antibody, 20ul Immune Repertoire Sequencing Alternatively spliced transcript variants encodingHLA DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes,