Smad3 Polyclonal Antibody, 50ul[BT-AP08391] Bottles the encoded protein complexes with

the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes

The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site| together with the large subunit of U2 auxiliary factor (U2AF)| and is required for the early stages of spliceosome assembly

The hes related family bHLH transcription factor with YRPW motif 2 forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription

It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers

Smad3 Polyclonal Antibody, 50ul[BT-AP08391] Bottles the encoded protein complexes withThe protein encoded by SMAD3 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor beta and is thought to play a role in the regulation of