BID (Cleaved-Arg71) Rabbit Polyclonal Antibody, 50ul Serum The other two isoforms| p52Shc

The other two isoforms| p52Shc and p46Shc| link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex

The gene is located in a region deleted in pediatric rhabdoid tumors of the brain

three pseudogenes are located on chromosomes 9

This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment

BID (Cleaved-Arg71) Rabbit Polyclonal Antibody, 50ul Serum The other two isoforms| p52ShcIntact BH3 motif is required by BIK BID BAK BAD and BAX for their pro apoptotic activity and for their interaction with anti apoptotic members of the Bcl 2 family. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1 isoform 2 and isoform 4 induce ICE like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl 2. PTM: Phosphorylated upon DNA damage probably by