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Therefore, it appears that schistosome TGR fulfills all of the major functions of the mammalian TGR, TrxR1, TrxR2, and GR orthologs, emphasizing the importance of the parasite protein, and this alone should make it an attractive target for treatment of schistosomiasis

In the context of ME/CFS and Long COVID, where glucose metabolism is often dysregulated and insulin resistance can develop, the ability to efficiently burn fats for energy becomes paramount