CD274 Polyclonal Antibody, 100ul Peripheral Blood Separation Tube Chromosomal rearrangements and altered expression

Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma

but scantily in adult tissues

and thus represents a nonreceptor-type isoform of this PTP

The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation| suggesting a cell cycle function

CD274 Polyclonal Antibody, 100ul Peripheral Blood Separation Tube Chromosomal rearrangements and altered expressionThis gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V like and C like domains. Interaction of this ligand with its receptor inhibits T cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is