Raf-1 Polyclonal Antibody, 50ul[BT-AP13537] Custom Peptide Synthesis The protein associates with the

The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein

Binding to the H1F0 promoter is enhanced by interaction with RB1

Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens

The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction

Raf-1 Polyclonal Antibody, 50ul[BT-AP13537] Custom Peptide Synthesis The protein associates with theThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.