DNA-PK(Phospho Thr2609) Rabbit Polyclonal Antibody, 50ul Vacuum Aspirator Loss of function compound heterozygous

Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype

This gene encodes a member of the ancient conserved domain protein family

and granulocytes

and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34

DNA-PK(Phospho Thr2609) Rabbit Polyclonal Antibody, 50ul Vacuum Aspirator Loss of function compound heterozygousCatalytic activity: ATP + a protein = ADP + a phosphoprotein. enzyme regulation: Inhibited by wortmannin. Activity of the enzyme seems to be attenuated by autophosphorylation. Serine threonine protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing