MerTK Polyclonal Antibody, 50ul Mechanical Pipette Mutations in this gene lead

Mutations in this gene lead to spinal muscle atrophy with respiratory distress type 1

This gene also has an alternative translation initiation site| resulting in a protein that lacks the N-terminal signal peptide

This protein is a component of several histone deacetylase complexes| though it silences genes by functioning as a histone demethylase

and auditory defects

MerTK Polyclonal Antibody, 50ul Mechanical Pipette Mutations in this gene leadMERTK is a member of the MER AXL TYRO3 receptor kinase family and encodes a transmembrane protein, tyrosine protein kinase mer, with two fibronectin type III domains, two Ig like C2 type (immunoglobulin like) domains, and one tyrosine kinase domain. Mutations in MERTK have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).