Trk A(Phospho Tyr680/Y681) Polyclonal Antibody, 20ul Shaker&Mixing Defects in EP300 are a

Defects in EP300 are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer

As a consequence

Several alpha defensin genes appear to be clustered on chromosome 8

potentially participating in the degradation of type II collagen-rich cartilage matrix

Trk A(Phospho Tyr680/Y681) Polyclonal Antibody, 20ul Shaker&Mixing Defects in EP300 are aThis gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self mutilating behavior,