NPS-2143 ycin aminonucleoside 4-benzodioxin-6-yl)-2

4-benzodioxin-6-yl)-2

Flow cytometry analysis following SR18662 treatment shows an increase in cells captured in either S or G2/M phases of the cell cycle and a significant increase in the number of apoptotic cells

S)-AHPC free base

NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor

NPS-2143 ycin aminonucleoside 4-benzodioxin-6-yl)-2NPS 2143 (SB 262470A), an orally active calcilytic agent, is a selective and potent calcium ion sensing receptor (CaSR) antagonist. NPS 2143 (SB 262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. Product information CAS Number: 284035 33 2 Molecular Weight: 408. 92 Formula: C24H25ClN2O2 Synonym: SB 262470A Related CAS Number: 324523 20