SAG - Hedgehog Agonist. CAS# 912545-86-9 ral-LSB It abrogated DNA damaged checkpoints

It abrogated DNA damaged checkpoints induced by gemcitabine

InChi: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

[Epub ahead of print] PubMed PMID: 24064905

SAG - Hedgehog Agonist. CAS# 912545-86-9 ral-LSB It abrogated DNA damaged checkpointsSAG, CAS NO. 912545 86 9, is a potent, selective, and cell permeable small molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3 derived Shh LIGHT2 cells and counteracts Cyclopamine KAAD inhibition of Smo. It was reported that SAG acts as an activator at low