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AM630 - CAS# 164178-33-0 Catalog No.:M10110-2 84(1):52-8

AM630 - CAS# 164178-33-0 Catalog No.:M10110-2 84(1):52-8

Name: AM630 - CAS# 164178-33-0 Catalog No.:M10110-2 84(1):52-8
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AM630 - CAS# 164178-33-0 Catalog No.:M10110-2 84(1):52-8Iodopravadoline, also known as AM630, is an inverse agonist at the human cannabinoid CB1 receptor. Iodopravadoline has been found to attenuate the ability of a number of cannabinoids to inhibit electrically evoked twitches of the mouse isolated vas deferens. AM630 was markedly more potent as an antagonist of delta 9 THC and CP 55,940 (Kd = 14. 0 and 17. 3 nM respectively) than as an antagonist of WIN 55,212 2, AM356 or anandamide (Kd = 36. 5, 85. 9

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Description

84(1):52-8

This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis

Stimulation with 6

the liver is the target organ in each of the three species investigated

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