S0859 - CAS# 1019331-10-2 AD(OMe)-FMK Chemical Name: 4-{6-[6-(4-methylpiperazin-1-yl)-1H-1

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S0859 - CAS# 1019331-10-2 AD(OMe)-FMK Chemical Name: 4-{6-[6-(4-methylpiperazin-1-yl)-1H-1S0859 is a selective, high affinity generic NBC inhibitor, potentially important for probing the transporter's functional role in heart and other tissues. S0859 reversibly inhibited NBC mediated pH(i) recovery (K (i)=1. 7 microM, full inhibition at approximately 30 microM). In HEPES buffered superfusates, NHE mediated pH(i) recovery was unaffected by 30 microM S0859. With CO(2) HCO(3) ( ) buffer, pH(i) recovery from intracellular alkalosis (mediated

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