WZ3146 Size:10mg solid 40 μM) inhibits pancreatic cancer

40 μM) inhibits pancreatic cancer cell invasion and cell growth

Sanaid SI-60

356559-20-1

InChi: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7

WZ3146 Size:10mg solid 40 μM) inhibits pancreatic cancerWZ 3146 is a covalent or irreversible pyrimidine based EGFR inhibitor against EGFR T790M. WZ 3146 was identified by screening an irreversible kinase inhibitor library specifically against EGFR T790M. WZ 3146 potently suppresses the growth of EGFR T790M containing cell lines and inhibits EGFR phosphorylation. WZ 3146 is also effective in murine models of lung cancer driven by EGFR T790M. WZ 3146 may be clinically more effective and better tolerated