AMG-208 - CAS# 1002304-34-8 K-4827 Tosylate PubMed PMID: 23991670

PubMed PMID: 23991670

3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1

18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20

ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19

AMG-208 - CAS# 1002304-34-8 K-4827 Tosylate PubMed PMID: 23991670AMG 208 is a selective small molecule inhibitor of the proto oncogene c Met with potential antineoplastic activity. c Met inhibitor AMG 208 inhibits the ligand dependent and ligand independent activation of c Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c Met. C Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell