SB505124 - CAS# 694433-59-5 0022 Nicholson JR

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SB505124 - CAS# 694433-59-5 0022 Nicholson JRSB505124, CAS No. 694433 59 5, is a selective inhibitor of transforming growth factor type I receptor (ALK5, ALK4 and ALK7) with potential anticancer activity. SB505124 selectively inhibits signaling from TGF and activin; does not inhibit other ALK family members. SB 505124 selectively and concentration dependently inhibits ALK4 , ALK5 , and ALK 7 dependent activation of downstream cytoplasmic signal transducers, Smad2 and Smad3, and of TGF beta

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